Our Technology

We offer a range of products and services, including several biosensors with differing functionalities, greater robustness and sensitivities than those currently on market. The company has also developed a platform technology which enables rapid design and construction of bespoke biosensors tailored to the specific needs of the customer. A further development is a portable device which will enable biosensor assessment to be made on site and in remote locations. License agreements to employ our biosensors, training courses for their application and data analysis as well as consultation on best measures for remediation of contamination are also available.

 

 

 
 
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Whole-Cell Biosensors

Our biosensors are unique biological detectors, based on environmental bacteria able to be used in both saline and freshwater applications without pre-treatment.

We currently have two market-ready biosensors; a ‘general’ or ‘acute’ toxicity biosensor, and a ‘geno-’ toxicity biosensor. These sensors allow the user to determine the combined toxic effect of all the substances within a sample, and also the specific ability of the components to cause gene-damage. They are engineered to produce easily-measurable light, which changes in the presence of toxic compounds. The subsequent change in light is then measured, indicating the overall toxicity of the sample. The mechanisms of toxicity are then further analysed using our suite of positive controls, and results are related to our extensive in-house database.

We are currently designing additional, specific biosensors to sensitively detect individual elements or parameters based on a switch-on light system, so only the specific compound or element of interest will activate the sensor. Unlike regularly used Vibrio fisherii (a light-producing marine bacterium used by many other toxicity testing companies), our sensors have been carefully engineered using synthetic biology. This increases sensitivity, improves reliability in complex media and different temperatures, decreases reaction time, and reduces the time-consuming need to adjust the salinity of your sample before testing.

 
 
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Platforms

Our biosensors are currently available for extensive in-house laboratory testing of your samples and we can perform a range of assays including cyto- and geno- toxicity assessments. In parallel, we are working on a new electronic platform for our biosensors to be used quickly and easily in the field, allowing affordable and rapid in situ data collection in environmental and industrial settings. Please contact us if you wish to be be involved or kept informed on our progress.

 
 
 
 
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Applications

We are constantly discovering new applications for our biosensors. Just some areas we are exploring are:

  • Monitoring the efficiency of wastewater treatment plants;

  • Detecting pollution in rivers, lakes and seas;

  • Sensing surges of heavy metals and pesticides in road run-offs;

  • Catching heavy metal contamination in fish farms before fish stocks are lost;

  • Testing for toxicity in brownfield sites;

  • Helping design easily-degradable new products e.g. dyes, biocides, anti-microbials etc.

 
 
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Modelling

The wealth of information provided by our biosensors, combined with physical and chemical measurements, provides an enormously valuable set of data. We are working on creating new mathematical models to add value to our biosensor data, enabling us to provide more detail and information on the causes of toxicity than ever before. In addition, we are developing a new model for toxicity along river systems, based on hydrological modelling to examine the effects on river toxicity of land-use change, climate change, factory location and pollution loading.